As a therapist supporting clients through depression, I frequently encounter questions about how therapy and antidepressants work together. Clients frequently ask “can therapy help me get off antidepressants?” Through research and clinical experience, I’ve come to understand that while both tools have their unique benefits, their synergy can be particularly powerful in managing depression. Also, through learning coping skills and insights in therapy, you may no longer need medications.
Combining Medication and Therapy
Antidepressants are often the first line of defense against depression. They work by altering brain chemistry to help improve mood and alleviate depressive symptoms. However, these medications are not a one-size-fits-all solution. Over time, the effectiveness of antidepressants can plateau, leaving individuals feeling stuck or without further improvement.
How Therapy Helps With Depression
Therapy empowers individuals to explore underlying factors of depression, equipping them with lasting skills to manage and transform their emotional experiences. Therapy empowers individuals with the tools to manage their depression, beyond what medication alone can offer. (CBT is just one evidence based treatment modality and there are plenty more like EMDR Therapy and DBT that can also help.)
The Research Backs This Up
Research supports combining antidepressants with therapy. While medication may relieve symptoms quickly, therapy often has a longer-lasting impact. This dual approach addresses both the biological and psychological aspects of depression. A meta-analysis of 115 studies has shown that CBT is an effective treatment strategy for depression and combined treatment with pharmacotherapy is significantly more effective than pharmacotherapy alone. Additionally, combined therapy has been found to result in a superior enduring effect compared to antidepressants alone in patients with major depression.
The Concern with Long-term Antidepressant Use
A growing concern in the field is the prolonged use of antidepressants without adequate support through therapy. Many individuals find themselves dependent on medication for years, often without a clear plan for tapering off or managing their depression without pharmaceutical aid. This reliance can lead to a sense of helplessness, as if the medication is the only lifeline. The usefulness of the medication may plateau over time.
Transitioning Away from Medication
Many people wish to manage their depression without medication, whether due to side effects or a desire for greater autonomy. This desire can stem from various reasons such as side effects, the wish to manage depression through non-pharmaceutical means, or the sense of being ‘stuck’ on medication.
Also, from a philosophical sense, it’s helpful to feel like you are making yourself better and not the medication making you better. It’s essential for people on medication to have access to information and support that facilitates a safe and gradual transition away from medication, ideally under the guidance of a healthcare professional. Integrating therapy during this transition can provide the necessary tools and skills to manage depression and maintain mental wellness in the absence of medication.
Empowering Individuals to Take Control
As professionals, it’s crucial to educate and empower our clients. While antidepressants play a vital role, therapy provides the skills and tools necessary to regain control over one’s mental health. It’s about building resilience, understanding the triggers and patterns of depressive thoughts and behaviors, and learning how to counteract them.
Can therapy help me get off antidepressants?
A Personal and Professional Perspective
On a personal note, I’ve seen the transformation in my clients when they engage in both medication management and therapy. The journey isn’t always easy, but the combination of these approaches provides a more comprehensive and effective way to combat depression. It’s about finding a balance and understanding that while medication can help manage symptoms, therapy teaches you how to live with and overcome depression. Modalities like CBT can help reframe challenges and EMDR can help you to work through PTSD, as an example. The goal is to teach you techniques and insights through treatment to hopefully no longer need medication but this should be in coordination with your prescriber.
If you or a loved one is navigating depression, consider the support of therapy alongside medication. Together, these tools can offer a path to not only manage depression but to thrive. Let’s embrace this holistic approach to mental health and support each other in this journey towards healing and well-being.
Below is a video on coming off of anti-depressants and what to expect.
Author: William Schroeder, LPC
This blog post is for informational purposes only and should not substitute professional medical advice. Always consult with a healthcare provider for personalized treatment options.


